Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19

Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19

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Xanthine oxidase (XO) is an enzyme that catalyzes the production of uric acid and superoxide radicals from purine bases: hypoxanthine and xanthine and is click here also expressed in respiratory epithelial cells.Uric acid, which is also considered a danger associated molecule pattern (DAMP), could trigger a series of inflammatory responses by activating the inflammasome complex path and NF-κB within the endothelial cells and by inducing proinflammatory cytokine release.Concurrently, XO also converts the superoxide radicals into hydroxyl radicals that further induce inflammatory responses.

These conditions will ultimately sum up a hyperinflammation condition commonly dubbed as cytokine storm syndrome (CSS).The expression of proinflammatory cytokines and neutrophil chemokines may be reduced by XO inhibitor, as observed in human respiratory syncytial virus (HRSV)-infected A549 cells.Our review emphasizes that XO may have an rubbermaid 8 gallon trash can essential role as an anti-inflammation therapy for respiratory viral infection, including coronavirus disease 2019 (COVID-19).